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Intrathecal injection of exendin-4 reduced pain sensitivity as assessed by the von Frey test and decreased neuroinflammation, with reduced TNF, IL-1β and IL-6 levels, thus demonstrating that analgesic effects of GLP-1R signalling were directly correlated with its anti-neuroinflammation activity [89]

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In contrast, shorter-acting GLP-1RAs such as exenatide are rapidly cleared and do not maintain chronic receptor occupation

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